An Aqueous leaf extract of Pyrenacanthia Staundtii
(AqPs) was studied for central nervous activities. The extract (100.0 -400.0 mg/kg i. p). significantly (p<0.05) inhibited acetic-acid induced abdominal constriction, and both the early and or late phases of formalin-induced paw licking in mice. AqPs (100-400mg/kg i.p.) also demonstrated a protective effect against strychnine-induced convulsion. The extract potentiated the hypnotic effect of hexobarbitone following i.p. injection at the dose levels studied. The results suggested that AqPs possesses potential analgesic, anticonvulsive and hypnotic properties.