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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 2, No. 2, 2005, pp. 153-165
Bioline Code: tc05017
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 2, No. 2, 2005, pp. 153-165

 en Research Paper - STUDIES ON THE ANXIOLYTIC EFFECT OF Spondias mombin check for this species in other resources L. (ANACARDIACEAE) EXTRACTS
A. O. Ayoka, R. O. Akomolafe, E. O. Iwalewa and O. E. Ukponmwan

Abstract

Spondias mombin check for this species in other resources L [Anacardiaceae] is a plant used by traditional medical practitioners in Nigeria in the treatment of various nervous disorders. In this study, the anxiolytic properties of the aqueous, methanol and ethanol extracts of the leaves were examined using aggressive-behaviour response and depression-related swimming behaviour activities. All the extracts administered orally were not toxic to mice up to a dose of 5 g/kg. On intraperitoneal injection, however, the LD50 values [mice/rats] were calculated to be 0.48 g/kg / 0.62 g/kg for ethanol extract, 1.10 g/kg / 1.08 g/kg for methanol extract and 1.36 g/kg / 1.42 g/kg for aqueous extract respectively. All residues from different extractions were dissolved in normal saline and administered intraperitoneally. It was found that the three extracts abolished the aggressive attacks by rats, and reduced swimming time in mice. These effects were found to be most potent with the administration of the ethanol extract. These effects of the extracts were blocked by flumazenil, an antagonist of GABAA receptor. The results suggest that the extracts of Spondias mombin possess anxiolytic effect mediated by GABAergic transmission.

Keywords
Spondias mombin, neurological, muricidal, swimming despair, GABA receptor antagonist.

 
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