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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 2, No. 3, 2005, pp. 233-237
Bioline Code: tc05024
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 2, No. 3, 2005, pp. 233-237

 en Short communication- THE ANTIULCER EFFECTS OF THE METHANOL EXTRACT OF THE LEAVES OF ASPILIA AFRICANA check for this species in other resources (ASTERACEAE) IN RATS
Télesphore Benoît Nguelefack Pierre Watcho, Sylvie Lea Wansi, Ngetla Manyineh Mbonuh, Dieudonne Ngamga, Pierre Tane, Albert Kamanyi

Abstract

Aspilia africana check for this species in other resources (Asteraceae) is a plant currently used in Cameroon ethnomedicine for the treatment of stomach ailments. The methanol extract of the leaves of A. africana was investigated against gastric ulcerations induced by HCl/ethanol and pylorus-ligation. With both methods, the extract inhibited gastric ulcerations in a dose-related manner. Oral administration of the plant extract at the doses of 0.5 and 1 g/kg reduced gastric lesions induced by HCl/ethanol by 79 % and 97 % respectively. The extract at the dose of 1 g/kg reduced gastric lesion in the pylorus ligated rats by 52 % although the gastric acidity remained higher as compared to the control. These findings show that methanol extract of the leaves of A. africana possess potent antiulcer properties.

Keywords
Aspilia africana, antiulcer, rat

 
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