search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 2, No. 3, 2005, pp. 253-258
Bioline Code: tc05027
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 2, No. 3, 2005, pp. 253-258

 en VASCULAR PERMEABILITY- INCREASING EFFECT OF THE LEAF ESSENTIAL OIL OF OCIMUM GRATISSIMUM check for this species in other resources LINN AS A MECHANISM FOR ITS WOUND HEALING PROPERTY.
Lara O. Orafidiya, F. A. Fakoya, E. O. Agbani and E. O Iwalewa

Abstract

Persistent microvascular hyperpermeability to plasma proteins is a characteristic feature of normal wound healing. Does the leaf essential oil of Ocimum gratissimum check for this species in other resources heal wounds by promoting this feature? Evan's blue dye (20mg/kg body weight) in normal saline was administered intravenously through marginal ear vein of experimental rabbits (n=5). Each animal served as its own control. One hour after Evan's blue dye administration, 0.1ml each of Ocimum oil, histamine dihydrochloride (30μg/ml) and normal saline were randomly administered by intra-dermal injection at the prepared sites on each of the animals. Increase in vascular permeability was assessed by dye effusion test. Analysis of the differences in vascular permeability between treatment groups showed that, Ocimum oil, in intensity and duration, was significantly (p<.05) more effective in increasing cutaneous capillary permeability over a 24h period after treatment. The ability of Ocimum oil in increasing vascular permeability may be one of the factors that contribute to its wound healing property.

Keywords
Ocimum gratissimum, vascular permeability, mechanism of action.

 
© Copyright 2005 - African Journal Traditional, Complementary and Alternative Medicines
Alternative site location: http://journals.sfu.ca/africanem/index.php/ajtcam

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2017, Site last up-dated on 05-Dec-2017.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil