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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 2, No. 3, 2005, pp. 326-336
Bioline Code: tc05035
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 2, No. 3, 2005, pp. 326-336

 en THE CONTRIBUTION OF THE ANTICHOLINESTERASE ACTIVITY OF PEDIALANTHUS TITHYMALOIDE check for this species in other resources TO ITS MOLLUSCICIDAL ACTIVITY
Sudhanshu Tiwari, Sunil K.Singh, Ajay Singh

Abstract

Experiments were conducted to evaluate the molluscicidal and anticholinesterase activity of aqueous leaf and stem-bark extract of Pedialanthus tithymaloide check for this species in other resources (Family- Euphorbiaceae) Lymnaea ( Radix) acuminata check for this species in other resources (Lamarack) and Indoplanorbis exustus check for this species in other resources (Deshyas) - intermediate hosts of endemic schistosomiasis and fascioliasis diseases in cattle and livestock. The toxic effect of both extracts was time-as well as dose-dependent. There was a significant negative correlation between LC values and exposure periods observed, thus the LC10 values of P. tithymaloide leaf decreased from 24.7 mg/L (24 h) to 15.4 mg/L (96 h); LC50 decreased from 69.4 mg/L (24 h) to 27.4 mg/L (96 h); LC90 decreased from 194.6 mg/L (24 h) to 48.9 mg/L (96 h) against L. acuminata and LC10 values of P. tithymaloide leafdecreased from 5.5 mg/L (24 h) to 0.6 mg/L (96 h); LC50 decreased from 35.8 mg/L (24 h) to 4.3 mg/L (96 h); LC90 decreased from 233.1 mg/L (24 h) to 32.1 mg/L (96 h) against Indoplanorbis exustus check for this species in other resources . Similar trend was also observed for the aqueous stem-bark extract of P.tithymaloide. Sub-lethal exposure at 24h and 96h of the aqueous leaf and stem-bark extract of P. tithymaloide causedsignificant (P < 0.05) time- and dose-dependent inhibition of the activity of enzyme acetylcholinesterase (AChE) in the nervous tissues of L. acuminata after 24 h or 96 h exposure periods.Withdrawal study also shows that there was a significant recovery in the acetylcholinesterase activity in both the tissues of snail after the 7th day of the withdrawal of treatment.Thus, the aqueous extract of P. tithymaloide leaf and stem-bark are environmentally safe candidate molluscicides for controlling vector snails of schistosomiasis and fascioliasis.

Keywords
Schistosomiasis and Fascioliasis, Pedialanthus tithymaloide, Molluscicidal, Anticholinesterase activity

 
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