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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 3, No. 1, 2006, pp. 44-53
Bioline Code: tc06005
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 3, No. 1, 2006, pp. 44-53

 en ANTINOCICEPTIVE, ANTI-INFLAMMATORY AND CYTOTOXIC ACTIVITIES OF PENTACLETHRA MACROPHYLLA check for this species in other resources AQUEOUS EXTRACTS IN MICE.
C. C. Okorie; E. N. T. Oparaocha;C. O. Adewunmi; E. O. Iwalewa and S. K.Omodara

Abstract

The aqueous leaf, stem – bark, seed and fruit pericarp extracts of Pentaclethra macrophylla check for this species in other resources were examined for their cytotoxicity, while only the leaves and seeds were tested for analgesic and anti-inflammatory activities using in-vivo and in-vitro experimental models. Cytotoxicity haemagglutination assay revealed the following order of toxicity among the plant parts: fruit pericarp > stem - bark > seed > leaf with 71.4, 25.6, 5.3, and 0.5 haemagglutination titre values respectively. The extracts at 30 and 60 mg/kg exhibited analgesic activity and anti-inflammatory property using the flick and hot plate tests, acetic acid induced writhing test; and leucocyte counts, pulmonary oedema and oedema paw of mice in a dose-dependent manner. These findings therefore explain and justify ethnomedical uses of Pentaclethra macrophylla in the treatment of itching (inflammatory response) and pain in animals and in man.

Keywords
Pentaclethra macrophylla, analgesic, anti-inflammatory, toxicity activities.

 
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