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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 3, No. 1, 2006, pp. 54-63
Bioline Code: tc06006
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 3, No. 1, 2006, pp. 54-63

 en ANTI-INFLAMMATORY ACTIVITY OF EXTRACTS OF ROOT BARK OF S ECURIDACA LONGIPEDUNCULATA check for this species in other resources FRES (POLYGALACEAE)
C. O Okoli., P. A . Akah and Ezugworie, U.

Abstract

The effect of extract and fractions of the root bark of Securidaca longipedunculata check for this species in other resources Fres (Polygalaceae) on acute inflammation was evaluated. Solvent extraction yielded the crude methanol extract (ME) while solvent guided extraction yielded a petroleum ether fraction (PF) and methanol fraction (MF). The extract and fractions inhibited topical edema induced by xylene in the mouse ear. In the systemic edema of the rat paw, the methanol extract (ME) and methanol fraction (MF) significantly (P<0.05) suppressed the development of paw edema induced by egg albumin in rats while the petroleum ether fraction (PF) was devoid of such activity.Ulcerogenic assay in rats indicated that the extract and fractions exhibited varying degrees of gastric irritation in rats in the order of magnitude: MF > PF > ME. Phytochemical tests showed that ME and MF tested positive for carbohydrates, reducing sugars, glycosides, flavonoids, terpenoids, sterols and saponins while PF gave positive reaction for resins only.Acute toxicity test for ME in mice established an i.p and p.o LD50 of 11 and 282 mg/kg respectively.

Keywords
Securidaca longipedunculata, root bark, acute inflammation, systemic edema.

 
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