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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 3, No. 1, 2006, pp. 129-136
Bioline Code: tc06014
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 3, No. 1, 2006, pp. 129-136

 en HYPOGLYCAEMIC AND ANTIDIABETIC EFFECT OF ROOT EXTRACTS OF CEIBA PENTANDRA check for this species in other resources IN NORMAL AND DIABETIC RATS
Paul Désiré Dzeufiet Djomeni; Léonard Tédong ; Emmanuel Acha Asongalem; Théophile Dimo ; Selestin Dongmo Sokeng; Pierre Kamtchouing

Abstract

The effect of the root bark extract of Ceiba pentandra check for this species in other resources (Linn) in normal and streptozotocin-induced diabetic rats was studied. Blood glucose levels were determined after oral administration of graded doses of C. pentandra (40, 75,150 and 300 mg/kg) in fasted normal and diabetic groups. In both groups, 40 and 75 mg/kg of the extract, significantly reduced blood glucose levels 8 h after administration, which was consistent and time-dependent. C. pentandra at the lower dose of 40mg/kg produced blood -glucose-lowering effect of 40.0% and 48.9%, in normal and diabetic rats respectively when compared with control rats. The higher doses of 150 and 300 mg/kg did not affect significantly the blood glucose levels. In multiple dose studies, the diabetic rats were treated orally by gavages, twice a day for 3 days. On day 3, C. pentandra (40 and 75mg/kg) significantly decreased blood and urine glucose levels as compared to initial values. The 14 h fasting blood glucose concentration was lowered by 59.8 % and 42.8% at the doses of 40 and 75 mg/kg and the corresponding urine glucose levels reductions were 95.7% and 63.6%, respectively. The results indicated that C. pentandra possessed hypoglycaemic effect. The plant extract was capable of ameliorating at lower doses, hyperglycaemia in streptozotocin-induced diabetic rats and could be a potential source for isolation of new orally active agent(s) for anti-diabetic therapy.

Keywords
Ceiba pentandra, Plant extract, Diabetes mellitus, Hypoglycaemic.

 
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