search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 3, No. 1, 2006, pp. 137-141
Bioline Code: tc06015
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 3, No. 1, 2006, pp. 137-141

 en Short communication- IN VIVO ANTIMALARIAL AND CYTOTOXIC PROPERTIES OF ANNONA SENEGALENSIS check for this species in other resources EXTRACT
Edith Ajaiyeoba, Mofolusho Falade, Omonike Ogbole, Larry Okpako and Dora Akinboye

Abstract

The in vivo animal antimalarial and in vitro cytotoxic activities of the methanol extract of Annona senegalensis check for this species in other resources Pers. (Annonaceae) was investigated in this study. The in vivo antimalarial activity of the methanol extract against Plasmodium berghei check for this species in other resources was assessed using the 4-day suppressive test procedure. The extract of A. senegalensis had intrinsic antimalarial property that were dose – dependent. At doses of 100mg/kg weight of mice, it produced significant chemosuppression of parasitemia (> 57%) when administered orally. It had the highest activity at 800mg/kg weight of mice (91.1%) compared to Chloroquine disphosphate, the standard reference drug which had a chemosuppression of 96.2%. The in vitro cytotoxicity evaluations were perfomed using A2780 ovarian cancer cells in the drug sensitivity assay. Extract of A. senegalensis exhibited low cytotoxicity with an IC50 of 28.8μg/ml. Preliminary phytochemical screening of the plant extract indicated the presence of alkaloids, saponins, tannins and cardiac glycosides. This finding supports the traditional use of the plant for the treatment of malaria.

Keywords
Annona senegalensis, Mice Antimalarial, Cytotoxicity, Plasmodium berghei

 
© Copyright 2006 - African Journal Traditional, Complementary and Alternative Medicines
Alternative site location: http://journals.sfu.ca/africanem/index.php/ajtcam

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2017, Site last up-dated on 05-Dec-2017.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil