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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 3, No. 2, 2006, pp. 84-93
Bioline Code: tc06020
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 3, No. 2, 2006, pp. 84-93

 en ANTIBACTERIAL EFFECTS OF SOME CAMEROONIAN MEDICINAL PLANTS AGAINST COMMON PATHOGENIC BACTERIA.
Moses N. Ngemenya, James A. Mbah, Pierre Tane and Vincent P.K.Titanji

Abstract

We screened forty crude extracts of twenty Cameroonian medicinal plants commonly used to treat bacterial infections for broad spectrum antibacterial activity, as a more affordable alternative against resistant organisms. The extracts were screened on common pathogenic gram negative and gram positive bacteriainitially by the disc diffusion method followed by the tube dilution method. Using discs containing 30µg of extract, Escherichia coli check for this species in other resources coli showed sensitivity to 23 extracts with diameter of zone of inhibition ranging from 7 – 19mm, fifteen of which were up to or > 10mm. Pseudomonas aeruginosa check for this species in other resources was sensitive to 11 extracts, whereas Salmonella typhimurium check for this species in other resources and Staphylococcus aureus check for this species in other resources were not sensitive to any of the extracts. Based on the zones of inhibition the activity of the extracts were equivalent to 30 to 138 % efficacy of the standard antibiotic discs. The lowest Minimum Inhibitory Concentration (MIC) recorded was 2 mg/ml for Euphorbia hirta check for this species in other resources against S. aureus and P. aeruginosa and the lowest Minimum Bactericidal Concentration (MBC) was 6 mg/ml for six extracts from Ageratum conyzoides check for this species in other resources , Aframomum citratum check for this species in other resources , Euphorbia hirta, Momordica charantia check for this species in other resources , Mangifera indica check for this species in other resources and Khaya senegalensis check for this species in other resources against three bacterial species. Three extracts had broad spectrum bacteriostatic activity (MICs ≤ 4 mg/ml) while in terms of MBCs none of the extracts showed broad spectrum bactericidalactivity. We conclude that most of the tested plants used as traditional antibacterials have a bacteriostatic effect on gram-negative pathogenic bacteria.

Keywords
plant extracts, broad spectrum, bacteriostatic, bactericidal

 
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