Human African Trypanosomiasis (sleeping sickness) cause considerable mortality and morbidity throughout the world with Trypansoma brucei
, T. gambiense
and T. brucei rhodesiense
as the major causative agents. The Terminalia ivorensis
gradient extracts were tested against T. brucei
rhodesiense parasites and the E.D50
values of 11.11 and 12.32 μg/mL were obtained for the ethyl acetate and ethanolic gradient extracts respectively. The column fractions of the ethyl acetate fraction gave E.D50
value between 1.98 and 5.46 μg/mL for the very active fractions indicating prospect for the development of potential trypanocidal agent from the plant.