search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 3, No. 2, 2006, pp. 42-50
Bioline Code: tc06025
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 3, No. 2, 2006, pp. 42-50

 en HYPOGLYCAEMIC ACTION OF THE FLAVONOID FRACTION OF Artocarpus heterophyllus check for this species in other resources LEAF
Chandrika U. G, Wedage W. S., Wickramasinghe S. M. D. N and Fernando W. S

Abstract

Hot water extract of mature jak leaves ( Artocarpus heterophyllus check for this species in other resources ) is recommended by Ayurvedic and traditional medical practitioners as a treatment for diabetes mellitus. The leaf extract caused the hypoglyceamic effect at a dose of 50 mg/Kg, both in normal and alloxan-diabetic rats. The hypoglycaemic effect was at its maximum 2 h after flavonoid fraction administration, and multiple dosing maintained the activity for a week. The hypoglycaemic effect of the flavonoid fraction of leaf (49%) is higher than that of tolbutamide (27.0%), a sulphonyl urea drug commonly used for treatment of hyperglycaemia. Administering the flavonoid fraction for 3 months had no significant effects on liver function while the histology of liver, kidney and heart revealed no damage. These results indicate that the total flavonoid content of A. heterophyllus leaf exhibited a non-toxic and significant hypoglycaemic activity in male Wistar rats and may therefore be responsible for the previously reported antidiabetic activity.

Keywords
Artocarpus heterophyllus, flavonoids, hypoglycaemic, rats

 
© Copyright 2006 - African Journal Traditional, Complementary and Alternative Medicines
Alternative site location: http://journals.sfu.ca/africanem/index.php/ajtcam

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2017, Site last up-dated on 05-Dec-2017.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil