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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 3, No. 3, 2006, pp. 22-31
Bioline Code: tc06033
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 3, No. 3, 2006, pp. 22-31

 en STUDY ON ANTIGENOTOXIC EFFECTS OF MOROCCAN MEDICINAL PLANTS AND SPICES USING THE WHITE/WHITE+ SOMATIC ASSAY IN DROSOPHILA
Nadya Mezzoug, Jamal Abrini, Andres Muñoz Serano, Angeles Alonso-Moraga and Mohamed Idaomar

Abstract

The antigenotoxic action of a selection of medicinal plants and spices from Morocco including laurel ( Laurus nobilis check for this species in other resources ), rosemary ( Rosmarinus officinalis check for this species in other resources ), verbena ( Verbena triphylla check for this species in other resources ), fenugreek ( Trigonella foenum-graecum check for this species in other resources ) and nutmeg ( Myristica fragrens check for this species in other resources ) was assessed using the eye white/white+ (w/w+) Somatic Mutation and Recombination Test (SMART) assay of Drosophila melanogaster check for this species in other resources . Methyl methanesulfonate (MMS) was used as a positive mutagenic compound inducing high frequencies of spots in Drosophila larvae. The frequencies of spots per eyes of a treated series are compared to those of its concurrent positive control series using χ2- test for evaluation of the antigenotoxic effect. The nutmeg at 1% (w/v) demonstrated a marked decrease in MMS-induced spots with an inhibition rate of 50%. Rosemary, fenugreek seeds and laurel showed different inhibition rates with different level of significance.

Keywords
Antigenotoxicity; Medicinal plants; Spices; w/w+ SMART assay; Drosophila; MMS.

 
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