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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 3, No. 3, 2006, pp. 80-86
Bioline Code: tc06040
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 3, No. 3, 2006, pp. 80-86

 en (4-METHOXY-BENZO[1,3]DIOXOL-5-YL)-PHENYLMETHANONE: AN ANTIBACTERIAL BENZOPHENONE FROM SECURIDACA LONGEPEDUNCULATA
Joseph, C. C., Moshi, M. J., Sempombe, J. and Nkunya, M.H.H.

Abstract

The dichloromethane extract of Securidaca longepedunculata check for this species in other resources Fresen yielded a benzophenone, (4-methoxy-benzo[1,3]dioxol-5-yl)-phenylmethanone (1), together with otherthree known compounds, 1,7-dihydroxy-4-methoxyxanthone (2), benzyl 2-hydroxy-6-methoxybenzoate (3), and methyl 2-hydroxy-6-methoxybenzoate (4). Compound (1) exhibited antibacterial activity against Pseudomonas aeruginosa check for this species in other resources , and antifungal activity against Aspergillus fumigatus check for this species in other resources . Compound 2 exhibited antibacterial activity against Staphylococcus aureus check for this species in other resources , and antifungal activity against Aspergillus niger check for this species in other resources , Aspergillus fumigatus and a Penicillum check for this species in other resources species. Compounds 3 and 4 were inactive against all the tested bacteria and fungi. These results provide proof of efficacy of the extracts of S.longepedunculata in treating bacterial infections, but further studies should be carried out to ascertain these results with respect to the widely reported traditional use.

Keywords
Securidaca longepedunculata, Antimicrobial, Benzophenone, (4-Methoxy-benzo[1,3]dioxol-5-yl)-phenylmethanone

 
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