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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 3, No. 4, 2006, pp. 23-33
Bioline Code: tc06049
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 3, No. 4, 2006, pp. 23-33

 en EFFICACY OF STANDARDISED HERBAL EXTRACTS IN TYPE 1 DIABETES - AN EXPERIMENTAL STUDY
Sarika Jain, P. Pandhi, A.P. Singh, Samir Malhotra

Abstract

In the present study, the hypoglycemic activity of Withania somnifera check for this species in other resources Dunal, Allium sativum check for this species in other resources Linn., Gymnema sylvestre check for this species in other resources (Retz.) Schult, Ferula foetida check for this species in other resources (Bunge.) Reg. and Murraya koenigii check for this species in other resources (L.) Spreng. extracts have been studied in an experimental model of type 1 diabetes. Type 1 diabetes was induced in albino rats by a single intraperitoneal injection of streptozotocin (60 mg/kg). Rats with fasting blood glucose (FBG) more than 250 mg/dl, 72 h after STZ administration, were treated with extracts of above mentioned medicinal plants. The fasting blood glucose was determined every week for 3 weeks by the glucose oxidase method. STZ-administration led to a highly significant elevation in FBG levels. The percent decrease in FBG levels from STZ-induced hyperglycemia was 43.3 ± 27.8, 48.2 ± 22.4 and 48.2 ± 7.9, after 3 weeks of treatment with standardised extracts of Withania somnifera (1.5% withanolides), Allium sativum (0.6% allicin) and Gymnema sylvestre (75% gymnemic acid), respectively. The fall in blood glucose with the herbal extracts was less when compared to insulin. In the vehicle treated group, there was 8.8 ± 9.3 percent increase in blood glucose values at the third week of treatment and in insulin treated group, percent decrease in blood glucose from the values obtained at 72 h after STZ-administration was 63.5 ± 4.9. Ferula foetida (60% ferulic acid) and Murraya koenigii extracts did not show any hypoglycemic effect in animal model of type 1 diabetes.

Keywords
Herbal extracts, Withania somnifera, Allium sativum, Gymnema sylvestre, Experimental type 1 diabetes.

 
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