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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 3, No. 4, 2006, pp. 34-41
Bioline Code: tc06050
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 3, No. 4, 2006, pp. 34-41

 en Research Paper - INVESTIGATION OF ANTIPLASMODIAL COMPOUNDS FROM TWO PLANTS, COCHLOSPERMUM TINCTORIUM check for this species in other resources A. RICH AND GARDENIA SOKOTENSIS check for this species in other resources HUTCH
M. Traoré, A Guiguemdé, I.Yago., J.B. Nikièma, H. Tinto, Z.P. Dakuyo, J.B. Ouédraogo, I.P. Guissou, T.R. Guiguemdé

Abstract

Efforts in malaria treatment are currently directed towards the discovery and development of new antimalarial compounds. In this way two plants Cochlospermum tinctorium check for this species in other resources A. Rich. (Cochlospermaceae) and Gardenia sokotensis check for this species in other resources Hutch (Rubiaceae) traditionally used to treat symptoms of malaria in Burkina Faso were screened for antimalarial activity in vivo with Plasmodium berghei check for this species in other resources . Dichloromethane extract of Cochlospermum tinctorium and dichloromethane-methanol (7/3v/v) of Gardenia sokotensis showed a promising in vivo antiplasmodial activity with 50% effective dose of 17.59 mg/kg and 115 mg/kg respectively. Water extracts from the two plants showed an interesting antiplasmodial activity of Cochlospermum tinctorium and a weak activity for Gardenia sokotensis. Paradoxically chromatographic fractions issued from the active crude extract of Cochlospermum tinctorium appear less active. The fraction FGs2 of Gardenia has showed a pronounced activity with 42% inhibition rate at 50 mg /kg. These results reflected in part the previous in vitro studies conducted on the two plants. Phytochemical screening revealed mostly the presence of triterpenes, carotenoids and flavonoids more or less in pure state.

Keywords
Cochlospermum tinctorium; Gardenia sokotensis; Malaria; Plasmodium berghei

 
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