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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 3, No. 4, 2006, pp. 66-73
Bioline Code: tc06053
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 3, No. 4, 2006, pp. 66-73

 en EVALUATION OF ANTIDIARRHOEAL ACTIVITY OF THE FRUIT-RIND OF PICRALIMA NITIDA check for this species in other resources (APOCYNACEAE)
Kouitcheu Mabeku Laure B., Penlap Beng V. , J. Kouam , Bonaventure T. Ngadjui , Z. T. Fomum, Etoa F. X

Abstract

The methanol (M) extract of the fruit-rind of Picralima nitida check for this species in other resources (PN) (Apocynaceae) was tested for its anti-diarrhoeal activity. Like loperamide (3 mg/kg body weight), a single oral dose of PN-M (375, 750 mg/kg body weight) produced a significant decrease in the frequency of defecation and severity of diarrhoea. To understand the mechanism of its anti-diarrhoeal activity, its effect was further evaluated on intestinal transit; castor oil-induced intestinal fluid accumulation (enteropooling) and electrolyte concentration in the small intestinal fluid. PN-M produced a decrease in intestinal transit (18.81-21.86%) as compared to castor oil treated animals. Unlike atropine, PN-M significantly inhibited castor oil-induced enteropooling. However it did not alter the electrolyte concentration in intestinal fluid as compared to castor oil treated rats.

Keywords
Picralima nitida, antidiarrhoeal activity, castor oil

 
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