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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 4, No. 1, 2007, pp. 23-36
Bioline Code: tc07011
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 4, No. 1, 2007, pp. 23-36

 en ANTIMICROBIAL ACTIVITIES AND TOXICITY OF CRUDE EXTRACT OF THE P SOPHOCARPUS TETRAGONOLOBUS check for this species in other resources PODS
L. Yoga Latha, S. Sasidharan, Z. Zuraini, S. Suryani, L. Shirley, S. Sangetha and M. Davaselvi

Abstract

The extract of the Psophocarpus tetragonolobus check for this species in other resources pods has been tested for antimicrobial activity in a disk diffusion assay on eight human pathogenic bacteria and two human pathogenic yeasts. The extracts of P. tetragonolobus possessed antimicrobial activity against all tested strains. The ethanolic extract of P. tetragonolobus pods was further tested for in vivo brine shrimp lethality test and in vitro sheep erythrocyte cytotoxic assay. The brine shrimp lethality test exhibited no significant toxicity (LC50=1.88 mg/ml) against Artemia salina, whereas sheep erythrocyte test showed significant toxicity. The reason for haemolysis of erythrocyte was discussed. The P. tetragonolobus extract with high LC50 value signified that this plant is not toxic to human. This result also suggested that the ethanolic extract of P. tetragonolobus pods is potential source for novel antimicrobial compounds.

Keywords
Antimicrobial activities; Artemia salina; Cytotoxicity assay; P. tetragonolobus .

 
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