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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 4, No. 2, 2007, pp. 226-230
Bioline Code: tc07021
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 4, No. 2, 2007, pp. 226-230

 en ANTICONVULSANT ACTIVITY OF DIOSPYROS FISCHERI check for this species in other resources ROOT EXTRACTS
Mainen J.Moshi, Zakaria H. Mbwambo, Ramadhani S.O. Nondo, Pax J. Masimba, Modest C. Kapingu and Edward S. Magelewanya.

Abstract

Diospyros fischeri check for this species in other resources Gurke (Ebenaceae) is used in traditional medicine for the treatment of epilepsy. Dichloromethane, ethylacetate, and ethanol extracts of theroots, at doses between 100 and 1600 mg/kg BW, inhibited convulsions induced by the γ-aminobutyric acid type A (GABAA) receptor antagonist, pentylenetetrazole (PTZ), in a dose dependent manner. The extracts also exhibited low toxicity against brine shrimps giving LC50 values between 45 .4 and 95.4 μg/ml. These results provide evidence for the potential of D. fischeri extracts to treat absence seizures, especially given their seemingly innocuous nature.

Keywords
Diospyros fischeri; Pentylenetetrazole; Anticonvulsant activity; Brine shrimp toxicity

 
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Alternative site location: http://journals.sfu.ca/africanem/index.php/ajtcam

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