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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 4, No. 2, 2007, pp. 173-184
Bioline Code: tc07028
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 4, No. 2, 2007, pp. 173-184

 en ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF SOME NIGERIAN MEDICINAL PLANTS
A. J. Aladesanmi, E. O. Iwalewa, A. C. Adebajo, E. O. Akinkunmi, B. J. Taiwo, F. O. Olorunmola and A. Lamikanra

Abstract

Ten Nigerian plants suggested from their ethnomedical uses to possess antimicrobial and antioxidant activities were studied for their anti-microbial and anti-oxidant properties. Antimicrobial activity was tested against Escherichia coli check for this species in other resources NCTC 10418, Pseudomonas aeruginosa check for this species in other resources , Staphylococcus aureus check for this species in other resources , Bacillus subtilis check for this species in other resources , Candida albicans check for this species in other resources , Candida pseudotropicalis check for this species in other resources and Trichophyton rubrum check for this species in other resources (clinical isolate). Trichilia heudelotti check for this species in other resources leaf extract showed both antibacterial and antifungal activities and was the most active against all the strains of bacteria tested. Boerhavia diffusa check for this species in other resources , Markhamia tomentosa check for this species in other resources and T. heudelotti leaf extracts inhibited the gram negative bacteria E.coli and P. aeruginosa strains whereas those of M. tomentosa, T. heudelotti and Sphenoceutrum jollyamum check for this species in other resources root inhibited at least one of the fungi tested. At a concentration of 312 μg/ml, hexane and chloroform fractions of T. heudelotti extract inhibited 6 and 14% of the fifty mult-idrug resistant bacteria isolates from clinical infectins, respectively.At ≤ 5mg/ml, the CHCl3 (64%) and aqueous (22%) fractions of T. heudelotti and those of CHCl3 (34%) and EtOAC (48%) of M. tomentosa gave the highest inhibition that wasstronger than their corresponding methanol extracts. The corresponding EC50 of the extracts on M. acuminata, T. heudelotti, E. senegalensis and M. tomentosa were 4.00, 6.50, 13.33, and 16.50 ig/ml using the TLC staining and 1,1-dipheyl-2-picry-hydrazyl (DPPH) free radical scavenging assay. Therefore, leaf extracts of M. tomentosa and T. heudelotti, especially the latter, possess strong antimicrobial and antioxidant activities and should be further investigated. These activities justified the ethnomedical uses of these plants.

Keywords
Antimicrobial, antifungal, antioxidant properties, Nigerian medicinal plants.

 
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