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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 4, No. 2, 2007, pp. 157-164
Bioline Code: tc07030
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 4, No. 2, 2007, pp. 157-164

 en BIOLOGICAL ACTIVITIES OF Schefflera leucantha check for this species in other resources
Buppachart Potduang, Chanchai Chongsiriroeg, Yaowaluck Benmart, Rattanasiri Giwanon, Winai Supatanakul and Sayan Tanpanich

Abstract

This study investigated various biological activities of the ethanolic extract of dried ground leaves of Schefflera leucantha check for this species in other resources Viguier(Araliaceae). The extract possessed very low cytotoxicity to brine-shrimp with the LC50 of 4,111.15mg/ml; the significant antioxidant activity on DPPH with the EC50 of 71.90 μg/ml; the inhibitory activity on mushroom tyrosinase with the IC50 of 10.53mg/ml using the dopachrome microplate-assay. The extract of 5-20mg/ml range in the agar dilution assay were active against various pathogenic microbial (11 species, 11 strains), with the minimum inhibitory concentration (MIC) of 5mg/ml against Clostridium spp.; MIC=10mg/ml against enteropathogens as Bacteroides check for this species in other resources spp., Enterococcus faecalis check for this species in other resources ATCC 29212, Lactobacillus check for this species in other resources spp., Peptococcus check for this species in other resources spp. and Streptococcus mutans check for this species in other resources ; MIC=10mg/ml against a pneumonia causing bacteria Klebsiella pneumoniae check for this species in other resources and a dermatopathogen as Propionibacterium acnes; MIC=20mg/ml against dermatopathogens as Staphylococcus aureus check for this species in other resources ATCC 6538, Streptococcus spp. and Candida albicans check for this species in other resources ATCC 90028. TLC fingerprints of the specific extracts from the leaf powder exhibited zones of steroids-terpenes and flavonoids. HPLC fingerprint of the flavonoid extract was performed.

Keywords
Schefflera leucantha, Antioxidant, Antityrosinase, Antimicrobial activity, Phytochemistry

 
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