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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 4, No. 2, 2007, pp. 140-147
Bioline Code: tc07032
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 4, No. 2, 2007, pp. 140-147

 en ACUTE AND SUBCHRONIC TOXICITY OF ANACARDIUM OCCIDENTALE check for this species in other resources LINN (ANACARDIACEAE) LEAVES HEXANE EXTRACT IN MICE.
Léonard Tédonga , Paul Désiré Djomeni Dzeufiet, Théophile Dimo, Emmanuel Acha Asongalem , Selestin Ndogmo Sokeng, Jean-François Flejou, Patrice Callard . Pierre Kamtchouing

Abstract

These studies focus on the toxicity leaf hexane extract of A. occidentale L (Anacardiaceae) used in Cameroon traditional medicine for the treatment of diabetes and hypertension. Previous findings on antidiabetic and anti-inflammatory have given support to the ethnopharmacological applications of the plant. After acute oral administration, it was found that doses of the extract less than 6 g/kg are not toxic. Signs of toxicity at high doses were asthenia, anorexia, diarrhoea, and syncope. The LD50 of the extract, determined in mice of both sexes after oral administration was 16 g/kg. In the subchronic study, mice received A. occidentale at doses of 6, 10 and 14 g/kg (by oral route) for 56 days. At doses of 2, 6 and 10 g/kg of extract, repeated oral administration to mice produced a reduction in food intake, weight gain, and behavioural effects. Liver or the kidney function tests were assessed by determining serum parameters like, creatinine, transaminases, and urea. All these parameters were significantly (p<0.01) abnormal. Histopatological studies revealed evidence of microcopic lesions either in the liver or in the kidney which may be correlated with biochemical disturbances. We conclude that toxic effects of A. occidentale L hexane leaf extract occurred at higher doses than those used in Cameroon folk medicine.

Keywords
Toxicity, Anacardum occidentale, Hexane extract, mice.

 
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