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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 4, No. 2, 2007, pp. 135-139
Bioline Code: tc07033
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 4, No. 2, 2007, pp. 135-139

 en THE ANTIPLASMODIAL AGENTS OF THE STEM BARK OF Entandrophragma angolense check for this species in other resources (MELIACEAE).
Jean Bickii, Guy Raymond Feuya Tchouya, Jean Claude Tchouankeu, Etienne Tsamo

Abstract

In the search of active principles from the stem bark of Entandrophragma angolense check for this species in other resources , we submitted the compounds isolated from the dichloromethane – methanol (1:1) extract of the stem bark to antimalarial test against chloroquine resistant strain W2 of Plasmodium falciparum check for this species in other resources malaria parasite. Only 7α- obacunyl acetate and a cycloartane derivative exhibited a good activity, with IC50s of 2 and 5.4 μg/ml respectively. Other compounds were moderately active.

Keywords
Plasmodium falciparum;Meliaceae; Entandrophragma angolense; Limonoids; Fatty acids; Triterpenoids; 7α- obacunyl acetate; 24-methylenecycloartenol; anti-plasmodial activity.

 
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