In the search of active principles from the stem bark of Entandrophragma angolense
, we submitted the compounds isolated from the dichloromethane – methanol (1:1) extract of the stem bark to antimalarial test against chloroquine resistant strain W2 of Plasmodium falciparum
malaria parasite. Only 7α- obacunyl acetate and a cycloartane derivative exhibited a good activity, with IC50
s of 2 and 5.4 μg/ml respectively. Other compounds were moderately active.