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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 4, No. 3, 2007, pp. 352-356
Bioline Code: tc07039
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 4, No. 3, 2007, pp. 352-356

 en ANTIBACTERIAL ACTIVITIES OF THE EXTRACTS AND CONESSINE FROM HOLARRHENA FLORIBUNDA check for this species in other resources G. DON. (APOCYNACEAE)
Patrice, Bogne Kamga; Véronique, Penlap Beng; David, Lontsi & François-Xavier, Etoa

Abstract

The methanolic extract and conessine isolated from the stem bark of Holarrhena floribunda check for this species in other resources (Hf) were tested for their antibacterial activities on Bacillus: Bacillus cereus check for this species in other resources , Bacillus subtilis check for this species in other resources , Bacillus megaterium check for this species in other resources and Bacillus stearothermophilus check for this species in other resources using the disc diffusion method. Phytochemical analysis of the crude extract and fractions was also conducted. The inhibition parameters of the crude methanol extract and the total alkaloid fraction were determined using the macrodilution method. The results showed that the crude extract, the total alkaloid fraction and conessine exhibited a significant antibacterial effect against all the strains studied. The antibacterial effect of conessine is almost similar to that of chloramphenicol used as reference. The ratio of the minimal bactericidal concentration (MBC) over the minimal inhibitive concentration (MIC) indicates the bactericidal effect of the plant. These results support common use of stem bark of Hf and conessine isolated from Hf in the treatment of some infectious diseases.

Keywords
Antibacterial activities, Holarrhena floribunda, Bacillus, conessine

 
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