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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 4, No. 3, 2007, pp. 289-293
Bioline Code: tc07046
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 4, No. 3, 2007, pp. 289-293

 en LIPID FRACTION CONSTITUENTS AND EVALUATION OF ANTI-ANAPHYLACTIC ACTIVITY OF PRUNUS MAHALEB L. check for this species in other resources KERNELS
Shams, Khaled A. & Schmidt, Richard

Abstract

The lipid fraction constituents as well as evaluation of anti-anaphylactic activity of PRUNUS MAHALEB L. check for this species in other resources Kernels were studied. Prunus mahaleb L. kernels were obtained from the local market in Cairo, Egypt. Investigation of the fatty acids revealed that oleic and linoleic acids are the major constituents. 12 compounds were identified from the hydrocarbon fraction. The sterol fraction comprises of cholesterol, stigmasterol, β-sitosterol and campesterol. The pharmacotoxicity studies were carried out on total and defatted ethanolic extracts as well as the oil fraction. The oil fraction proved to be extremely safe and free from any acute lethal toxicity in intraperitoneal (i.p.) and oral doses up to 100 ml/kg. In vivo assessment of prophylactic efficacy was afforded by 7 days course of daily medication schedule of sensitized adult male guinea pigs against ovalbumin bronchospasm. The prophylactic anti-inflammatory activity of the total ethanolic extract was higher than that of the defatted ethanolic extract. In addition, the lipid fraction of Prunus mahaleb L. kernels evoked complete anti-inflammatory efficacy among the survival animals receiving low and medium doses.

Keywords
Piptadenia africana, Leguminoseae, Glyceryl-1-hexacosanoate, Methyletherapigenin, Chemotaxonomy, Antibacterial activity.

 
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