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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 4, No. 3, 2007, pp. 261-266
Bioline Code: tc07050
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 4, No. 3, 2007, pp. 261-266

 en SPASMOGENIC EFFECT OF THE AQUEOUS EXTRACT OF TAMARINDUS INDICA L. check for this species in other resources (CAESALPINIACEAE) ON THE CONTRACTILE ACTIVITY OF GUINEA-PIG TAENIA COLI
Souza, A & Aka, K. J.

Abstract

The effect of aqueous extract of Tamarindus indica L. check for this species in other resources (AETI) was studied on the guinea pig taenia coli, due to its use for treatment of constipation in traditional medicines. AETI, at concentrations ranging from 10-8 mg/ml to 10-2 mg/ml, increased the spontaneous contractile activity of guinea pig taenia coli in a dose-dependent manner (EC50= 4x10-6 mg/ml). This activity was unaffected by atropine. In high K+, Ca2+-free solution containing EDTA, AETI as well as acetylcholine, used as a control, induced tonic contraction. These results suggest that the plant extract exert a spasmogenic effect that would not involve cholinergic mechanism of action. However, these active principles could mobilize both extra cellular calcium and intracellular calcium from internal stores.

Keywords
Contractions, Smooth muscle, Taenia coli, Tamarindus indica

 
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