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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 4, No. 4, 2007, pp. 411 – 416
Bioline Code: tc07058
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 4, No. 4, 2007, pp. 411 – 416

 en ANTI-INFLAMMATORY AND ANTI-NOCICEPTIVE ACTIVITIES OF METHANOLIC EXTRACT OF THE LEAVES OF FRAXINUS FLORIBUNDA check for this species in other resources WALLICH
Lingadurai, Sutharson; Nath, Lila Kanta; Kar1, Prasanna Kumar; Besra, Shila E. & Joseph, Rajan Vedasiromani

Abstract

Fraxinus floribunda Wallich (Family-Oleaceae) is a wide green tree in the sub-alpine region of Sikkim, India. The methanolic extract of the leaves of Fraxinus floribunda (MEFF) at 100, 200 and 400mg/kg/p.o was screened in rats for anti-inflammatory activity by acute-carrageenan induced paw edema, sub-acute cotton pellet induced granuloma and chronic Freund's adjuvant induced arthritis models. In all the three models of antiinflammatory studies 200 and 400mg/kg/p.o doses of the extract showed significant effect (P<0.001). Antinociceptive evaluation was performed by writhing and tail-immersion tests in mice. Anti-nociceptive evaluation revealed that MEFF at the dose of 400mg/kg/p.o had significant activity against the control. The relieving effect was through the peripheral and central mechanism of action of the extract. This study rationalized the ethno medicinal use of the plant for relieving pain in inflammatory pathological conditions like fracture and dislocation.

Keywords
Fraxinus floribunda, Carrageenan, Cotton pellet, Freund's adjuvant, Writhing test, Tail immersion test.

 
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