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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 4, No. 4, 2007, pp. 427 – 433
Bioline Code: tc07060
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 4, No. 4, 2007, pp. 427 – 433

 en SYNERGISTIC ANTIMICROBIAL ACTIVITIES OF PHYTOESTROGENS IN CRUDE EXTRACTS OF TWO SESAME SPECIES AGAINST SOME COMMON PATHOGENIC MICROORGANISMS.
Bankole, Munir A; Shittu, Lukeman A. J; Ahmed, Titilade.A; Bankole, Marian N; Shittu, Remilekun K; Kpela, Terkula & Ashiru, Oladapo A.

Abstract

Intensive studies on extracts and biologically active compounds isolated from medicinal plants have doubled in the last decade worldwide. However, as a result of paucity of knowledge and folkloric claim on the effectiveness of sesame leaves in infectious disease treatments, we aimed to determine the synergistic antimicrobial activity of essential oils and lignans present in the crude leaves extracts of Sesame radiatum check for this species in other resources and Sesame indicum check for this species in other resources . Ethanolic, methanolic and aqueous extracts of both leaves were studied for their in-vitro synergistic antimicrobial activity against both Gram positive and Gram negative micro-organisms, and Yeast using Agar diffusion method. The GC-MS phytochemical screening of methanolic extract showed that the major compounds in essential oils are of carboxylic acids and phenolic groups especially, the most potent antioxidants known to man like sesamol, sesamolin and sesamin among others. Methanolic and ethanolic extracts have broad spectrum antimicrobial effect against all the tested pathogenic micro-organisms except Streptococcus pneumoniae check for this species in other resources and Staphylococcus aureus check for this species in other resources respectively, while the aqueous extract exhibited inhibitory activity on Staphylococcus aureus, Streptococcus pneumoniae and Candida albicans check for this species in other resources . The result confirmed the folkloric claims of the antimicrobial effectiveness of locally consumed sesame leaves extracts especially against bacterial and common skin infection in many areas of Nigeria .

Keywords
Pathogenic micro-organisms, Gram-positive, Gram-negative,Yeast, Anti-microbial, Sesame leaves, GC-MS, MIC

 
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Alternative site location: http://journals.sfu.ca/africanem/index.php/ajtcam

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