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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 4, No. 4, 2007, pp. 524 – 528
Bioline Code: tc07069
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 4, No. 4, 2007, pp. 524 – 528

 en ANTI-DIARRHEAL ACTIVITY OF THE LEAF EXTRACTS OF DANIELLIA OLIVERI check for this species in other resources HUTCH AND DALZ (FABACEAE) AND FICUS SYCOMORUS MIQ (MORACEAE)
Ahmadua, A. A.; Zezib, A. U. & Yaro, A. H.

Abstract

The leaves of the plants Daniellia oliveri (Fabaceae) and Ficus sycomorus check for this species in other resources (Moraceae) used in diarrhea treatment in Hausa ethnomedicine of Northern Nigeria were investigated. The study was carried out on parfused isolated rabbit jejunum and castor oil-induced diarrhea in mice. The n-butanol extracts: NBD and NBF (0.16- 3.2mg/ml) caused a dose-dependent relaxation of isolated rabbit jejunum. The acute toxicity test for NBD and NBT in mice established an i.p LD50 of > 4000mg/kg for D. oliveri and 1131.4mg/kg for F. sycomorus. In castor oilinduced diarrhea, 80% protection was observed for D. oliveri at doses of 200mg/kg and 60% protection was observed at 100mg/kg and 50mg/kg respectively. For F. sycomorus 100% protection was observed at doses of 120mg/kg and 60mg/kg, for the n-butanol extract. The antidiarrheal activity was comparable to loperamide 5mg/kg. The result revealed that the extracts have pharmacological activity against diarrhea.

Keywords
Anti-diarrhea,castor oil,n-butanol extracts,tissue relaxation.

 
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