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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 5, No. 1, 2008, pp. 32-38
Bioline Code: tc08006
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 5, No. 1, 2008, pp. 32-38

 en ANTIGENOTOXIC EFFECT OF FERULIC ACID IN 7,12-DIMETHYL BENZ(A)-ANTHRACENE (DMBA) INDUCED GENOTOXICITY
Balakrishnan, Subramanian; Menon, Venugopal P.; Manoharan, Shanmugam & Rajalingam, Kasinathan

Abstract

The antigenotoxic effect of ferulic acid was carried out by evaluating the cytogenetic markers, the micronuclei frequency and chromosomal aberrations, in the bone marrow of hamsters in 7,12dimethylbenz(a)anthracene (DMBA) induced genotoxicity. Genotoxicity was induced in experimental hamsters by single intraperitoneal injection of DMBA (30mg kg-1 b.w). Pretreatment of ferulic acid orally at a dose of 40mg kg-1 b.w for five days significantly reduced the frequency of micronucleated polychromatic erythrocytes (MnPCEs) and the percentage of chromosomal aberrations in hamster's bone marrow. Our results thus suggest that ferulic acid has potent antigenotoxic effect in DMBA induced genotoxicity in golden Syrian hamsters.

Keywords
DMBA, ferulic acid, genotoxicity, chromosomal aberrations, lipid peroxidation, antioxidants, hamster.

 
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