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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 5, No. 1, 2008, pp. 46-50
Bioline Code: tc08008
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 5, No. 1, 2008, pp. 46-50

 en IN VIVO SCREENING OF ANTIMALARIAL ACTIVITY OF ACACIA MELLIFERA check for this species in other resources (BENTH) (LEGUMINOSAE) ON PLASMODIUM BERGHEI check for this species in other resources IN MICE
Mutai, Charles; Rukunga, Geoffrey; Vagias, Constatinos & Roussis, Vassilios

Abstract

The activities of total extracts and lupane triterpenes, isolated from the stem bark of Acacia mellifera,were evaluated against Plasmodium berghei strain ANKA in a female Swiss mouse model. Five isolated compounds and the crude extracts were evaluated for antimalarial activity and Quinine hydrochloride was used as a positive control. Only betulin and the methanolic extract produced considerable antimalarial activity in mice infected with P. berghei parasites. This study demonstrated the presence of bioactive agents in Acacia mellifera.

Keywords
Acacia mellifera, lupane triterpenes, Antimalarial activity, mice

 
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