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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 5, No. 1, 2008, pp. 92-96
Bioline Code: tc08014
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 5, No. 1, 2008, pp. 92-96

 en PHYTOCHEMICAL, ANALGESIC AND ANTI-INFLAMMATORY EFFECTS OF THE ETHYLACETATE EXTRACT OF THE LEAVES OF PSEUDOCEDRELLA KOTSCHYII check for this species in other resources
Musa, Y. M.; Haruna, A. K.; Ilyas, M.; Yaro, A. H.; Ahmadu, A. A. & Usman, H.

Abstract

Phytochemical screening was carried out on the ethylacetate portion of the ethanolic extract of the leaves of Pseudocedrella kotschyii and then evaluated for its analgesic (acetic acid-induced writhing) and anti-inflammatory (raw egg albumin-induced oedema) activities in mice and rats respectively. Phytochemical screening of the ethylacetate partition portion of ethanolic extract revealed the presence of flavonoids, glycosides and tannins as major chemical constituents. Alkaloids saponins, cardiac glycosides, steroids were not dictated in the extract. The ethylacetate extract (50 and 100 mg/kg i.p) exhibited significant activity (p<0.05) against acetic acid-induced writhing in a dose dependent manner. In the anti-inflammatory activity the ethylacetate extract (50 and 100 mg/kg i.p.) caused a slight effect against the raw egg albumin-induced oedema. The effect was however observed not to be dose dependent. All these effects were compared with standard drug piroxicam (20 mg/kg i.p.).

Keywords
Acetic acid-induced writhing; Analgesic; Anti-inflammatory; Meliaceae; Oedema; Phytochemistry; Pseudocedrella kotschyii.

 
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