search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 5, No. 2, 2008, pp. 141-146
Bioline Code: tc08019
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 5, No. 2, 2008, pp. 141-146

 en Anti-Nociceptive and Anti-Inflammatory Activities of Aqueous Leaves Extract of Ocimum Gratissimum check for this species in other resources ( Labiate ) in Rodents.
Tanko, Y.; Magaji, G. M.; Yerima, M.; Magaji, R. A. & Mohammed, A.

Abstract

The aqueous leaves extract of Ocimum Gratissimum check for this species in other resources was investigated for anti-nociceptive and anti-inflammatory effects in mice and rats. The models used to study the effect on nociception are the acetic acid-induced abdominal constriction test, hot- plate method in mice. The anti-inflammatory effect was investigated employing the formalin-induced hind–paw oedema in rats. The extract caused a significant (p<0.05), dose-dependent inhibition of acetic acid-induced writhing and hot-plate method .The extract also exhibited anti-inflammatory effect which was significant (P<0.001) at all the three doses. .The intraperitoneal LD50 value of the extract was 1264.9mg/kg body weight in mice. Preliminary phytochemical screening revealed the presence of alkaloids, saponins, tannins and flavonoids. The results suggest the extract contained pharmacologically active principles, and supports the local application of the plant in painful and inflammatory conditions.

Keywords
Ocimum grassitimum, anti-nociceptive, anti-inflammatory.

 
© Copyright 2008 - African Journal Traditional, Complementary and Alternative Medicines
Alternative site location: http://journals.sfu.ca/africanem/index.php/ajtcam

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2017, Site last up-dated on 16-Oct-2017.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil