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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 5, No. 2, 2008, pp. 147-153
Bioline Code: tc08020
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 5, No. 2, 2008, pp. 147-153

 en Behavioural Effects of the Methanolic Root Bark Extract of Securinega Virosa check for this species in other resources in Rodents
Magaji, M.G.; Anuka, J.A.; Abdu-Aguye, I.; Yaro, A.H & Hussaini, I. M.

Abstract

Securinega Virosa check for this species in other resources is used traditionally as sedative in children and in mental illnesses. In this study, the behavioral effects of methanolic root bark extract of S. virosa were investigated in mice. The results revealed that the extract significantly (P<0.05) and dose-dependently reduced the onset and prolonged the duration of sleep. The extract significantly (P<0.05) decreased exploratory activity and reduced the rate of apomorphine-induced stereotyped climbing at the doses tested (6.25-25mg/kg). It also produced a significant and dose-dependent motor coordination deficit in mice at the doses tested (P<0.01). The intraperitoneal median lethal dose in mice was 774.6mg/kg while the preliminary phytochemical screening revealed the presence of alkaloids, tannins, saponins and flavonoids. These results suggest that methanolic root bark extract of S. virosa contains biologically active principles that are sedative in nature and lend pharmacological credence to the ethnomedical use of the plant.

Keywords
Behaviour, Securinega virosa, motor coordination, exploratory activity, stereotyped climbing.

 
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