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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 5, No. 2, 2008, pp. 201-208
Bioline Code: tc08028
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 5, No. 2, 2008, pp. 201-208

 en Hypoglycaemic Activity of Nauclea Latifolia check for this species in other resources Sm. (Rubiaceae) in Experimental Animals.
Gidado, Abubakar; Danladi, A. Amehb; Sunday, E. Atawodib__PS & __Ibrahim, Sani

Abstract

Aqueous, ethanolic and hexane extracts of the leaves of Nauclea Latifolia check for this species in other resources (Rubiaceae) were assessed for their fasting blood glucose lowering effect in normoglycaemic and streptozotocin – diabetic rats. Wistar strain albino rats were given different doses of the extracts after 18 hrs fast and their blood glucose measured at 0,1,2,4 and 6 hours after treatment. The aqueous and ethanolic extracts significantly lowered the fasting blood glucose levels of the STZ–diabetic rats in a dose–dependent manner. The highest dose administered (400mg/kg) lowered the fasting blood glucose of the diabetic rats by 31.7% (aqueous) and 36.1% (ethanolic) extracts. The aqueous extract did not significantly lower the glucose levels of normoglycaemic rats (maximum 6.6%), nor was any significant decrease seen in the rats administered with the hexane (maximum of 4.0% for normoglycaemic and 2.4% for diabetics) extract. The hypoglycaemic and antihyperglycaemic potentials of the aqueous and ethanolic extracts were comparable to that of glibenclamide (1mg/kg).These results further support the traditional use of the plant in the treatment of diabetes mellitus.

Keywords
Nauclea latifolia; Diabetes mellitus; Hypoglycaemia; Streptozotocin – induced diabetes.

 
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