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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 5, No. 3, 2008, pp. 247-256
Bioline Code: tc08037
Full paper language: English
Document type: Review Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 5, No. 3, 2008, pp. 247-256

 en Studies On Effect Of Piperine On Oral Bioavailability Of Ampicillin And Norfloxacin
Janakiraman, Kunchithapatham & Manavalan, Rajappan

Abstract

Ampicillin and Norfloxacin are used to treat variety of bacterial infections. These two drugs have low oral bioavailability. Co-administration of Piperine (20mg/kg), an alkaloid from Piper nigrum check for this species in other resources L. enhanced oral bioavailability of Ampicillin and Norfloxacin in animal model. This is reflected in various pharmacokinetic measurements like Cmax, Tmax, AUC and t½ of the above antibiotics in animal model.

Keywords
Ampicillin, Bioavailability, Norfloxacin, Phamacokinetics, Piperine, Piper nigrum.

 
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