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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 6, No. 2, 2009, pp. 163 - 167
Bioline Code: tc09022
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 6, No. 2, 2009, pp. 163 - 167

 en Screening Of Traditionally Used Plants For In Vivo Antimalarial Activity In Mice
Innocent, Esther; Moshi, Mainen J.; Masimba, Pax J.; Mbwambo, Zakaria H.; Kapingu, Modest C. & Kamuhabwa, Appolinary

Abstract

Aqueous ethanol (80%) extracts of six plants used traditionally for treatment of malaria, Vepris glomerata check for this species in other resources (F.Hoffm.) Engl (Rutaceae), Maranthus floribunda check for this species in other resources (Bak.) F.White (Chrysobalanaceae), Strophanthus eminii check for this species in other resources Asch. & Pax ex Pax (Apocynaceae), Cassia abbreviata check for this species in other resources Oliv. (Leguminosae) and Caesalpinia bonducella check for this species in other resources L. Fleming (Fabaceae) were screened for antimalarial activity to establish validity of their claims. The extracts exhibited antimalarial activity in the 4-day Peter’s suppressive antimalarial assay in mice inoculated with red blood cells parasitized with Plasmodium berghei check for this species in other resources . The extracts gave ID50 values of 42.8, 111.0, 639.3 and 1560 mg/kg body wt for C. bonducella, C. abbreviata, T. furialis and S. eminii, respectively. The ID50 values for V. glomerata and M. floribunda were above 2400 mg/kg body wt, above which point solubility was a problem. All the tested extracts were innocuous to the mice, up to 2400 mg/kg body wt, suggesting they may be safe for short-term use.

Keywords
Antimalarial activity, Plasmodium berghei, traditional medicines

 
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