Extraction parameters of flavonoids from Ipomoea Batatas
leaf (FIBL) and anti-diabetic activity
of FIBL on alloxan induced diabetic mice were studied. The optimal extraction parameters of FIBL were
obtained by single factor test and orthogonal test, as follows: ethanol concentration 60 %, ratio of solvent to raw
material 30 , extraction temperature 75° and extraction time 1.5 h , while extraction yield of FIBL was 5.94 %.
FIBL treatment (50, 100, and 150 mg/ kg body weight) for 28 days resulted in a significant decrease in the
concentration of fasting blood glucose (FBG), total cholesterol (TC) and triglyceride (TG) in diabetes mellitus
mice. Furthermore, FIBL significantly increased body weight (bw) and serum high-density lipoprotein
cholesterol (HDL-c) level. The data demonstrated FIBL at the dose of 100 mg/kg bw exhibited the optimal effect.
The above results suggest that FIBL can control blood glucose and modulate the metabolism of blood lipid in
diabetes mellitus mice.