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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 6, No. 2, 2009, pp. 195 - 202
Bioline Code: tc09026
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 6, No. 2, 2009, pp. 195 - 202

 en The Optimal Extraction Parameters And Anti-Diabetic Activity Of Flavonoids From Ipomoea Batatas check for this species in other resources Leaf
Li, Fenglin; Li, Qingwang; Gao, Dawei & Peng, Yong

Abstract

Extraction parameters of flavonoids from Ipomoea Batatas check for this species in other resources leaf (FIBL) and anti-diabetic activity of FIBL on alloxan induced diabetic mice were studied. The optimal extraction parameters of FIBL were obtained by single factor test and orthogonal test, as follows: ethanol concentration 60 %, ratio of solvent to raw material 30 , extraction temperature 75° and extraction time 1.5 h , while extraction yield of FIBL was 5.94 %. FIBL treatment (50, 100, and 150 mg/ kg body weight) for 28 days resulted in a significant decrease in the concentration of fasting blood glucose (FBG), total cholesterol (TC) and triglyceride (TG) in diabetes mellitus mice. Furthermore, FIBL significantly increased body weight (bw) and serum high-density lipoprotein cholesterol (HDL-c) level. The data demonstrated FIBL at the dose of 100 mg/kg bw exhibited the optimal effect. The above results suggest that FIBL can control blood glucose and modulate the metabolism of blood lipid in diabetes mellitus mice.

Keywords
flavonoids from Ipomoea batatas leaf; extraction; anti-diabetic.

 
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