search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 6, No. 4, 2009, pp. 534 - 543
Bioline Code: tc09044
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 6, No. 4, 2009, pp. 534 - 543

 en Protection Of Swimming-Induced Oxidative Stress In Some Vital Organs by The Treatment Of Composite Extract Of Withania Somnifera check for this species in other resources , Ocimum Sanctum check for this species in other resources And Zingiber Officinalis check for this species in other resources In Male Rat
Misra, Debanka Sekhar; Maitia, Rajkumar & Ghosha, Debidas

Abstract

Composite methanolic extract of roots of Withania Somnifera check for this species in other resources , leaves of Ocimum Sanctum check for this species in other resources , and rhizomes of Zingiber Officinalis check for this species in other resources was administered by gavage at the dose of 40 mg 100 g−1 body weight day−1 to rat orally for 15 days prior to experimentation followed by co-administration of above extract at the same dose for 28 days of swimming to find out the remedial effect of this extract on exhaustive physical exercise-induced oxidative damage. Swimming resulted significant diminution (p<0.05) in the activities of catalase and superoxide dismutase along with elevation (p<0.05) in the levels of thiobarbituric acid reactive substances and conjugated dienes in cardiac, skeletal, hepatic tissues, cerebrum and cerebellum in respect to control. The levels of all these parameters were resettled significantly (p<0.05) towards the extract pretreated cum co-treated swimming group. The antioxidative potency of this composite extract was compared with standard non-enzymatic antioxidant (vitamin-E) in forced swimming state. The above extract has no general toxic effect as reflected here from the study of transaminase activities in liver and kidney. Results lead to conclude that the composite extract of above three plant parts has a therapeutic protective effect on forced swimming-induced oxidative stress in vital organs.

Keywords
Brain tissues, metabolic organs, oxidative stress, phytotherapy, swimming, vitamin-E.

 
© Copyright 2009 - African Journal Traditional, Complementary and Alternative Medicines
Alternative site location: http://journals.sfu.ca/africanem/index.php/ajtcam

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2017, Site last up-dated on 16-Oct-2017.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil