This study investigated antipruritic and anti-inflammatory effect of
Centella asiatica
extract in rats and
anti-allergic in vitro using sheep (
Capra hircus
) serum method and compound 48/80 induced mast cell
degranulation method, compared with standard drug ketotifen fumarate. In rats, extract of
Centella asiatica
administered orally was examined for anti-pruritic study and chlorpheniramine maleate was used as standard
drug while carageenan paw induced inflammatory method was used for the antiinfammatory study. The results show
that the extracts of
Centella asiatica exhibited antiallergic, anti-pruritic and anti-inflammatory activities.
