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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 7, No. 1, 2010, pp. 47-52
Bioline Code: tc10007
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 7, No. 1, 2010, pp. 47-52

 en Microanatomical effects of ethanolic extract of Cola nitida check for this species in other resources on the stomach mucosa of adult wistar rats
Ojo, Gideon B.; Nwoha, Polycarp U.; Ofusori, David A.; Ajayi, Sunday A.; Odukoya, Samson A.; Ukwenya, Victor O.; Bamidele, Olubayode; Ojo, Olumide A. & Oluwayinka, Oladele P.

Abstract

The study investigated the microanatomical effects of the extracts of Cola nitida check for this species in other resources on the stomach mucosa of adult male Wistar rats. Twenty adult male wistar rats were randomly divided into four equal groups of A, B, C and D (n=5). Animals in experimental groups B, C and D were given 600mg/kg body weight of crude extract of Cola nitida each by oral intubation for five, seven and nine consecutive days respectively, while group A (control) received equivalent volume of distilled water. Twenty four hrs after the last administration, the animals were sacrificed; tissues were harvested and fixed in 10% formol saline for histological analysis. The study revealed necrotized surface epithelium, degenerated gastric mucosa, and loss of glandular elements in the stomachs of experimental groups′ vis-a-vis the control group. These observations were days-dependent; as those groups which received the extract for higher number of days were seen to be adversely affected. In conclusion, Cola nitida at 600mg/kg body weight can cause gastric lesion in animals. This lesion may be pronounced if the administration continued for days. Cola nitida should, therefore, be taken with caution to avoid gastric complications.

Keywords
Cola nitida, necrotized, degenerated, stomach mucosa, microanatomy, glandular elements

 
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