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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 7, No. 1, 2010, pp. 53-58
Bioline Code: tc10008
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 7, No. 1, 2010, pp. 53-58

 en Antifungal activity of crude extracts of Gladiolus dalenii check for this species in other resources van geel (Iridaceae)
Odhiambo, Judith Agot; Siboe, George Muyala; Lukhoba, Catherine Wanjiru & Dossaji, Saiffudin Fidahussein

Abstract

Bulb extracts of Gladiolus dalenii check for this species in other resources reportedly used in the treatment of fungal infections in HIV/AIDS patients in the Lake Victoria region were tested for antifungal activity using the disc diffusion assay technique. Commercially used antifungal drugs, Ketaconazole and Griseofulvin (Cosmos Pharmaceuticals) were used as standards. Dichloromethane (CH2CL2)/Methanol (MeOH) in the ratio 1:1. Soluble extracts showed antifungal activity against Aspergillus niger. Direct bioautography on silica gel Thin Layer Chromatography (TLC) and appropriate spraying agents were used to identify the active component in the extract. The activities of both the extracts were higher than that of Griseofulvin. CH2CL2 soluble extract in addition showed ability to delay sporulation in A.niger. The active group of compounds in the extracts was identified as alkaloids, which offer immense potential for development of new and valuable pharmaceutical products.

Keywords
G. dalenii, Aspergillus niger, Antifungal activity

 
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