This study was carried to examine the effects of the aqueous leaf extract of Sesamum radiatum
,a laxative plant on
the contractile activity of Taenia caeci
, an intestinal smooth muscle. Strips of Taenia caeci
were rapidly removed from
guinea-pig and were suspended between two L-shaped stainless steel hooks in a 10 ml organ bath with Mac Ewen solution.
The isometric contractile force of the Taenia caeci
strips were recorded by using a strain gauge. S. radiatum
extract (ESera) is a spasmogenic substance. This myostimulant effect is characterized by the increase of the rhythm and the
amplitude of isolated guinea-pig Taenia caeci
smooth muscle in normal solution and by the development of contracture in
modified solution and in solution without calcium. A similar effect was observed with ACh which caused a graded increase
of the contractile activity of Taenia caeci
. The effects induced by ESera and ACh were reversed in the presence of atropine.
The spasmogenic effect induced by ESera could justify partially the use of S. radiatum
as laxative in traditional medicine.