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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 8, No. 4, 2011, pp. 377-385
Bioline Code: tc11048
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 8, No. 4, 2011, pp. 377-385

 en Myostimulating Effect of Sesamum Radiatum check for this species in other resources Aqueous Leaf Extract in Isolated Guinea-Pig Taenia Caeci check for this species in other resources Contractile Activity
Konan, André B; Amonkan, Augustin K; Ahui, Marie-Louise B; Bouafou, Guy-Marcel K; Kouakou, Léandre K; Kpahé, Fidèle Z & Datté, Jacques Y

Abstract

This study was carried to examine the effects of the aqueous leaf extract of Sesamum radiatum check for this species in other resources ,a laxative plant on the contractile activity of Taenia caeci check for this species in other resources , an intestinal smooth muscle. Strips of Taenia caeci were rapidly removed from guinea-pig and were suspended between two L-shaped stainless steel hooks in a 10 ml organ bath with Mac Ewen solution. The isometric contractile force of the Taenia caeci strips were recorded by using a strain gauge. S. radiatum aqueous leaf extract (ESera) is a spasmogenic substance. This myostimulant effect is characterized by the increase of the rhythm and the amplitude of isolated guinea-pig Taenia caeci smooth muscle in normal solution and by the development of contracture in modified solution and in solution without calcium. A similar effect was observed with ACh which caused a graded increase of the contractile activity of Taenia caeci. The effects induced by ESera and ACh were reversed in the presence of atropine. The spasmogenic effect induced by ESera could justify partially the use of S. radiatum as laxative in traditional medicine.

Keywords
Sesamum radiatum; acetylcholine; Taenia caeci; contractile activity

 
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