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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 8, No. 4, 2011, pp. 420-424
Bioline Code: tc11054
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 8, No. 4, 2011, pp. 420-424

 en Anti-inflammatory, Analgesic and Antipyretic Effects of Lepidagathis anobrya check for this species in other resources Nees (Acanthaceae)
Richard, Sawadogo Wamtinga; Marius, Lompo; Noya, Somé; Pierre, Guissou Innocent & Germaine, Nacoulma-Ouedraogo Odile

Abstract

This study investigated the general acute, anti-inflammatory, analgesic and antipyretic effects of methanol extract of Lepidagathis anobrya check for this species in other resources Nees (Acanthaceae). Carrageenan-induced rat paw edema and croton oil-induced ear edema in rats were used for the evaluation of general acute anti-inflammatory effects. Acetic acid- induced writhing response and yeast-induced hyperpyrexia in mice were used to evaluate the analgesic and antipyretic activities respectively. The extract at doses of 10, 25, 50 and 100 mgkg-1 for carrageenan test and doses of 0.5 mg/ear for croton oil test induced a significant reduction (p < 0.001) of paw and eat edemas in rats. In the analgesic and antipyretic tests, the extract has shown a significant inhibition of writhes and hyperpyrexia with all the doses used when compared to the untreated control group. These results clearly show the anti-inflammatory, analgesic and antipyretic effects of the methanol extract of Lepidagathis anobyra and give the scientific basis for its traditional use. Further studies are needed to clarify the mechanism of action and the components responsible for these pharmacological effects.

Keywords
Lepidagathis anobrya; anti-inflammatory; analgesic; antipyretic; acute toxicity

 
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