Antifertility effects of an aqueous leaf extract of
Oldenlandia affinis
on male rats were investigated. The extract was
administered intraperitoneally in sexually mature male rats at a dose of 24 mg/rat (n=8) for a total of eight injections over a 4
week period. There was a decrease in testis weights but all other accessory sex organs and vital organ weights were not affected
by treatment with
O. affinis extract. Testis histology revealed fewer spermatozoa or azoospermic seminiferous tubules in treated
animals compared to controls with no change in neither tubule thickness nor Sertoli cell structure.
O. affinis treatment caused a
17% decrease in sperm motility but there was no change in cauda epididymal sperm counts. However, serum testosterone levels
decreased significantly (P<0.05) in the experimental group (602.4 ± 57 ng/dL) compared to controls (808.9 ± 55 ng/dL). These
preliminary results show that the aqueous leaf extract of
O. affinis suppresses fertility parameters in male rats.