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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 8, No. 4, 2011, pp. 452-461
Bioline Code: tc11060
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 8, No. 4, 2011, pp. 452-461

 en Anacardium occidentale check for this species in other resources Linn. (Anacardiaceae) Stem Barks Extract Induces Hypotensive and Cardio-Inhibitory Effects in Experimental Animal Models
Tchikaya, Francis Olivier; Bantsielé, Guy Bernard; Kouakou-Siransy, Gisèle; Datté, Jacques Yao; Yapo, Paul Angoue; Zirihi, Noel Guedé & Offoumou, Michel Atté

Abstract

Anacardium occidentale check for this species in other resources Linn. (Anacardiaceae) is a plant largely used in Africa for the treatment of different diseases. In Côte d’Ivoire it’s commonly used for the treatment of hypertension. The present study was carried out in order to assess the effects of Anacardium occidentale extract (ANOE) on cardiovascular parameters in animal models. A mercury manometer kymograph of Ludwig was used to measure the blood pressure of normotensive rabbits in control conditions (normal physiological solution) and under the influence of ANOE. The contractile activity of an isolated rat heart was also measured in control conditions and under the influence of ANOE in different physiological media using a modified Langendhorff (1895) apparatus. The aqueous Anacardium occidentale (ANOE) bark extract applied intravenously in different doses (12, 40, 90, and 167 mg/kg b.w.), produced a significant dose-dependent decrease in blood pressure of previously normotensive rabbits (up to 89% vs control). Atropine (1 mg/ml) pre-treatment failed to reverse the hypotensive effects elicited by the extract. ANOE applied to isolated rat heart preparations in different concentrations (0.01, 0.1, 1.0, and 10 µg/ml) induced negative inotropic and chronotropic effects. Atropine pre-treatment of heart preparations (0.1 μg/ml) failed to reverse the negative effects induced by ANOE. The extract’s action on heart contractile activity studied in modified culture media further confirmed its cardio-inhibitory effects. ANOE induced strong hypotensive and cardio-inhibitory effects in animal models.

Keywords
Anacardium occidentale Linn. (Cashew); Hypotension; Cardio-depression

 
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