Linn. (Anacardiaceae) is a plant largely used in Africa for the treatment of different diseases.
In Côte d’Ivoire it’s commonly used for the treatment of hypertension. The present study was carried out in order to assess the
effects of Anacardium occidentale
extract (ANOE) on cardiovascular parameters in animal models. A mercury manometer
kymograph of Ludwig was used to measure the blood pressure of normotensive rabbits in control conditions (normal
physiological solution) and under the influence of ANOE. The contractile activity of an isolated rat heart was also measured in
control conditions and under the influence of ANOE in different physiological media using a modified Langendhorff (1895)
apparatus. The aqueous Anacardium occidentale
(ANOE) bark extract applied intravenously in different doses (12, 40, 90, and
167 mg/kg b.w.), produced a significant dose-dependent decrease in blood pressure of previously normotensive rabbits (up to
89% vs control). Atropine (1 mg/ml) pre-treatment failed to reverse the hypotensive effects elicited by the extract. ANOE applied
to isolated rat heart preparations in different concentrations (0.01, 0.1, 1.0, and 10 µg/ml) induced negative inotropic and
chronotropic effects. Atropine pre-treatment of heart preparations (0.1 μg/ml) failed to reverse the negative effects induced by
ANOE. The extract’s action on heart contractile activity studied in modified culture media further confirmed its cardio-inhibitory
effects. ANOE induced strong hypotensive and cardio-inhibitory effects in animal models.