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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 8, No. 5s, 2011, pp. 175-180
Bioline Code: tc11083
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 8, No. 5s, 2011, pp. 175-180

 en Investigation of the Antitrypanosomal Activity Buchholzia coriacea check for this species in other resources Seed Extract Against a Field Strain of Trypanosoma congolense check for this species in other resources
Nweze, N.E.; Anene, B.M. & Asuzu, I.U.

Abstract

The antitrypanosomal activity of the methanol extract of Buchholzia coriacea check for this species in other resources seed against a field strain of Trypanosoma congolense check for this species in other resources was investigated using experimentally infected mice of both sexes. Monitoring of parasitaemia was by the rapid matching technique. When parasitaemia was approximately log 7.8 (63 x 106 parasites/ml), treatment with graded doses of the extract (250, 500 and 1000 mg/kg) was instituted for 5 consecutive days. Diminazene diaceturate (Dimivet® SKM Pharma Pvt. Ltd.) was given at 3.5 mg/kg i.p. to the positive control mice. No significant differences in body weights were observed. The rectal temperatures of infected mice showed fluctuations. The PCV of infected mice were significantly (p < 0.05) lower than those of the uninfected controls. There was no significant difference between the PCV of the extract-treated and untreated animals. Parasitaemia increased steadily in the extract-treated and untreated mice groups till all the animals died. Three days post-treatment with diminazene diaceturate parasitaemia was cleared. Six days later, there was a relapse of infection. By the end of the experiment, a 50 % relapse rate was recorded in the diminazene diaceturatetreated group. The methanol extract of Buchholzia coriacea seeds did not show any antitrypanosomal activity in mice infected with Trypanosoma congolense at the doses tested.

Keywords
Trypanosoma congolense; Buchholzia coriacea; Antitrypanosomal activity

 
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