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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 8, No. 5s, 2011, pp. 226-232
Bioline Code: tc11090
Full paper language: English
Document type: Review Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 8, No. 5s, 2011, pp. 226-232

 en Anticancer Activities of Nigella sativa check for this species in other resources (Black Cumin)
Khan, Md. Asaduzzaman; Chen, Han-chun; Tania, Mousumi & Zhang, Dian-zheng

Abstract

Nigella sativa check for this species in other resources has been used as traditional medicine for centuries. The crude oil and thymoquinone (TQ) extracted from its seeds and oil are effective against many diseases like cancer, cardiovascular complications, diabetes, asthma, kidney disease etc. It is effective against cancer in blood system, lung, kidney, liver, prostate, breast, cervix, skin with much safety. The molecular mechanisms behind its anticancer role is still not clearly understood, however, some studies showed that TQ has antioxidant role and improves body’s defense system, induces apoptosis and controls Akt pathway. Although the anti-cancer activity of N. sativa components was recognized thousands of years ago but proper scientific research with this important traditional medicine is a history of last 2~3 decades. There are not so many research works done with this important traditional medicine and very few reports exist in the scientific database. In this article, we have summarized the actions of TQ and crude oil of N. sativa against different cancers with their molecular mechanisms.

Keywords
Traditional medicine; Nigella sativa; Thymoquinone; Antioxidant; Anti-cancer mechanism

 
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