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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 9, No. 1, 2012, pp. 138-152
Bioline Code: tc12019
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 9, No. 1, 2012, pp. 138-152

 en ANTI-INFLAMMATORY AND ANTIOXIDANT EFFECTS OF AN ETHANOLIC EXTRACT OF THE AERIAL PARTS OF HILLERIA LATIFOLIA check for this species in other resources (LAM.) H. WALT. (PHYTOLACCACEAE)
Abotsi, W.K.M.; Ainooson, G.K. & Woode, E.

Abstract

Various parts of the perennial herb Hilleria latifolia check for this species in other resources (Lam.) H. Walt. (Family: Phytolaccaceae) are used in Ghanaian traditional medicine for the treatment of several inflammatory-related disorders. The present study examined the anti-inflammatory effect of an ethanolic extract of the aerial parts of Hilleria latifolia (HLE) in acute and chronic inflammation models. Since free radicals and reactive oxygen species are implicated in inflammatory diseases, the antioxidant potential of HLE was also investigated in in vitro experimental models. HLE (10-300 mg kg-1, p.o.), either preemptively or curatively, significantly inhibited carrageenan-induced foot oedema in 7-day old chicks. Similarly, the NSAID diclofenac (10-100 mg kg-1, i.p.) and the steroidal anti-inflammatory agent dexamethasone (0.3-3 mg kg-1, i.p.) dose-dependently reduced the oedema in both pre-emptive and curative treatments. In the Freund’s adjuvant induced-arthritis model in rats, HLE as well as the positive controls, dexamethasone and methotrexate, showed significant anti-arthritic properties when applied to established adjuvant arthritis. HLE (10-300 mg kg-1, p.o.) significantly reduced oedema in the ipsilateral paw of rats but failed to prevent systemic arthritic spread. The DMARD methotrexate (0.1-1 mg kg-1, i.p.) and dexamethasone (0.3-3 mg kg-1, i.p.) reduced significantly the total polyarthritic oedema as well as the spread of the arthritis from the ipsilateral to the contralateral paws of the treated animals. The extract (0.03-1.00 mg ml-1) exhibited Fe3+ reducing activity, scavenged DPPH and prevented lipid peroxidation. These findings suggest that the extract exerts in vivo antiinflammatory activity after oral administration and also has antioxidant properties which may contribute to its activity.

Keywords
Carrageenan; chicks; DPPH; Freund’s adjuvant-induced arthritis; lipid peroxidation; total phenol

 
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