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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 9, No. 2, 2012, pp. 204-209
Bioline Code: tc12027
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 9, No. 2, 2012, pp. 204-209

 en ANTI-DIABETIC ACTIVITIES OF THE METHANOL LEAF EXTRACTS OF HYMENOCARDIA ACIDA check for this species in other resources (TUL.) IN ALLOXAN-INDUCED DIABETIC RATS
Ezeigbo, Ihechiluru I. & Asuzu, Isaac. U.

Abstract

The effect of methanolic extract of Hymenocardia acida check for this species in other resources leaves on diabetes and associated lipidemia were investigated on experimentally-induced diabetic rats. The extract did not demonstrate any acutely toxic effect in rats within the dose range (250 mg/kg - 2000 mg/kg) employed in the study; hence it was well tolerated by the rats. In all experiments, the anti-diabetic effects were dose-dependent and comparable to that of glibenclamide (2 mg/kg) standard. At a dose of 500 mg/kg, lipid profile markers such as the serum total cholesterol (TC) levels, LDL-C, triglycerides and HDL-C were significantly lower (p <0.05) than those of both the treated and untreated controls.

Keywords
Hymenocardia acida; Diabetes mellitus; Lipid profile; Glibenclamide; Alloxan monohydrate

 
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Alternative site location: http://journals.sfu.ca/africanem/index.php/ajtcam

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